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Nitric Oxide Colorimetric Detection Kit

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Shelf Life:

12 months

Introduction:

Nitric oxide (NO) is a diffusible, transient, reactive molecule that has physiological effects in the picomolarto-micromolar range. Acting through soluble guanylate cyclase activation, NO is an important physiological regulator of the cardiovascular, nervous, and immunological systems. NO is bio-available by two routes. It can be endogenously generated by constitutive or induced enzymes like Nitric Oxide Synthase or it can be orally ingested as nitrates and nitrites for rapid uptake into circulation and subsequent conversion. The reactive nature of nitric oxide allows it to act as a cytotoxic factor when released during an immune response by cells such as macrophages. It also allows NO to be easily converted to a toxic radical that can produce nitrosative damage to cells, organelles and molecules such as DNA. Nitrosaylation is also a regulated post-translational modification in cell signaling. The balance and dynamics of the regulatory/ damage facets of NO are major forces in mitochondrial signaling and dysfunction. NO is linked not only to coronary heart disease, endothelial dysfunctions, erectile dysfunction, and neurological disorders, but also diabetes, chronic periodontitis, autism, cancer, and assorted age-related diseases. The physical properties of Nitric Oxide make it challenging for direct detection methods. However, colorimetric methods can be applied to measure its stable break-down products, nitrate (-NO₃) and nitrite (-NO₂-).

Packaging:

2 plates

Storage Conditions:

Store at -20°C.

Tags:

Nitric Oxide Colorimetric Detection Kit

Target:

Nitric Oxide Colorimetric Detection Kit

It should be noted that our products are for research purposes only. Not suitable for any clinical use.

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