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Lysosomal Cytotoxicity Dual Staining Kit

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Description:

Lysosomes are membrane-bound organelles important for various cellular processes. They contain hydrolytic enzymes utilized in the metabolism of some biomolecules. The extracellular cargo (e.g. nutrients, toxins) binds to the cell membrane and is subsequently transported into membrane-bound endosomes for further degradation by lysosomes while intracellular components are transported to lysosomes through autophagy. Lysosomal dysfunction is associated with many human conditions such as aging and neurodegenerative disease.
Lysosomal Cytotoxicity Dual Staining Kit also contains two fluorescent probes: a membrane-permeable, selective lysosomal stain and a cell death marker. This easy-to-use kit can be used to study the regulation of lysosomal cytotoxicity at the cellular level and to screen for compounds that affect lysosomal function. Results can be obtained using fluorescence microscopy or flow cytometry.
A Positive Control which increases lysosome activity and staining serves as an experimental control.

Application:

For studying the regulation of lysosomal cytotoxicity in cultured cells by using fluorescence microscopy and flow cytometry.

Shelf Life:

12 months

Packaging:

50 assays

Storage Conditions:

Store at -20°C.

It should be noted that our products are for research purposes only. Not suitable for any clinical use.

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